Topicals represent a newer emerging market in medical marijuana products geared toward health and beauty. Cannabinoids can be absorbed through the skin for certain therapeutic benefits without any psychoactivity. Additionally, the essential oils in hemp and cannabis provide many benefits for skin health. From moisturizers to shampoos and deodorants, medical cannabis products continue to diversify.
Wild North American hemp is derived mostly from escaped European cultivated hemp imported in past centuries, perhaps especially from a revival of cultivation during World War II. Wild Canadian hemp is concentrated along the St. Lawrence and lower Great Lakes, where considerable cultivation occurred in the 1800s. In the US, wild hemp is best established in the American Midwest and Northeast, where hemp was grown historically in large amounts. Decades of eradication have exterminated many of the naturalized populations in North America. In the US, wild plants are rather contemptuously called “ditch weed” by law enforcement personnel. However, the attempts to destroy the wild populations are short-sighted, because they are a natural genetic reservoir, mostly low in THC. Wild North American plants have undergone many generations of natural adaptation to local conditions of climate, soil and pests, and accordingly it is safe to conclude that they harbor genes that are invaluable for the improvement of hemp cultivars. We have encountered exceptionally vigorous wild Canadian plants (Fig. 52), and grown wild plants from Europe (Fig. 53) which could prove valuable. Indeed, studies are in progress in Ontario to evaluate the agronomic usefulness of wild North American hemp. Nevertheless, present policies in North America require the eradication of wild hemp wherever encountered. In Europe and Asia, there is little concern about wild hemp, which remains a valuable resource.
In the UK, the Department for Environment, Food and Rural Affairs treats hemp as a purely non-food crop, but with proper licensing and proof of less than 0.2% THC concentration, hemp seeds can be imported for sowing or for sale as a food or food ingredient. In the U.S., imported hemp can be used legally in food products and, as of 2000, was typically sold in health food stores or through mail order.
Luke Zigovits, chief executive of Wisconsin-based Hemp Science, said, “We can finally relax. Because now we can source seed, now we can sell our product across state lines. Prohibition is over. It broadens horizons, allowing universities to do research, for example.” Beyond moving the industry into legitimacy, Zigovits said there are opportunities for tobacco farmers in Wisconsin and elsewhere to start growing industrial hemp crops as well.
The main difference between the two is in its chemical composition, specifically in tetrahydrocannabinol (THC). THC is the chemical responsible marijuana’s psychological effects.An average batch of marijuana contains anywhere from 5-20% THC content. Some premium marijuana can have up to 25-30% THC. Hemp, on the other hand, has a max THC level of 0.3%, essentially making it impossible to feel any psychoactive effect or get a “high”. This threshold is heavily regulated in other countries that have legalized hemp.Hemp also has high cannabidiol (CBD) content that acts as THC’s antagonist, essentially making the minimal amount of THC useless.
Cannabis played a large role in the Greco-Roman cultures as a source of both fiber, an intoxicant, and a medicine. Cannabis seeds were discovered in the ruins of Pompeii, and Greek rhetorician Athenaeus made note of hemp being used to make rope between 170 and 230 CE. Roman author and naturalist Pliny the Elder also made reference to a cannabis root decoction as a treatment for joint stiffness and gout in the first (1st) century BCE.
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Cannabis has an ancient history of ritual use and is found in pharmacological cults around the world. Hemp seeds discovered by archaeologists at Pazyryk suggest early ceremonial practices like eating by the Scythians occurred during the 5th to 2nd century BC, confirming previous historical reports by Herodotus. It was used by Muslims in various Sufi orders as early as the Mamluk period, for example by the Qalandars. Smoking pipes uncovered in Ethiopia and carbon-dated to around c. AD 1320 were found to have traces of cannabis.
There’s no definite amount that’s appropriate for everyone, but the ratio of CBD to THC will indicate how psychoactive the product is and if it’s legal in your state. The more CBD compared with THC, the less of a high, and vice versa. “Managing psychoactivity is key to successful cannabis therapy,” says Lee. “Amounts should be made clear on the label and lab-certified so people know what’s helping them and what’s not.”
μ-Opioid receptor agonists (opioids) (e.g., morphine, heroin, hydrocodone, oxycodone, opium, kratom) α2δ subunit-containing voltage-dependent calcium channels blockers (gabapentinoids) (e.g., gabapentin, pregabalin, phenibut) AMPA receptor antagonists (e.g., perampanel) CB1 receptor agonists (cannabinoids) (e.g., THC, cannabis) Dopamine receptor agonists (e.g., levodopa) Dopamine releasing agents (e.g., amphetamine, methamphetamine, MDMA, mephedrone) Dopamine reuptake inhibitors (e.g., cocaine, methylphenidate) GABAA receptor positive allosteric modulators (e.g., barbiturates, benzodiazepines, carbamates, ethanol (alcohol) (alcoholic drink), inhalants, nonbenzodiazepines, quinazolinones) GHB (sodium oxybate) and analogues Glucocorticoids (corticosteroids) (e.g., dexamethasone, prednisone) nACh receptor agonists (e.g., nicotine, tobacco, arecoline, areca nut) Nitric oxide prodrugs (e.g., alkyl nitrites (poppers)) NMDA receptor antagonists (e.g., DXM, ketamine, methoxetamine, nitrous oxide, phencyclidine, inhalants) Orexin receptor antagonists (e.g., suvorexant)
While it was originally believed that THC is a breakdown product of CBD, it is now known that both THC and CBD are actually metabolites of their decarboxylated acidic forms, THCa and CBDa. These acidic precursors are decarboxylated (essentially dried) by heat or extraction to produce THC and CBD; only then do they become psychoactive.The compound has medicinal benefits without the “high” that some patients do not desire. This makes CBD appealing to patients who are looking for an alternative to their current meds, which often have opiate-like effects.
We have been using cannabis oil with a 1:1 CBD/THC ratio from “AnnCannMed” in treating my husband with pancreatic cancer with a lot of improvement since 4 weeks and the product is working in a miraculous way beyond our expectations. The medication is working with super proof. We recommend you visit AnnCannMed for your health prescriptions and medical purchases and feel support talking to licensed physicians